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The mobile phase consisted of water with 0.1% formic acid (solvent A) and acetonitrile with 0.1% formic acid (solvent B), with a gradient elution program: 01.5 min at 2% B, 1.59 min with a linear gradient from 2% to 50% B, 914 min with a linear gradient from 50% to 95% B, and 1417 min at 95% B, all at a flow rate of 300 l/min

Taking into consideration the critical role of one-carbon metabolism as a producer of reducing power and building blocks, as well as its part in regulating substrates for epigenetic and post-translational modifications, an important line of questioning emerges

Leibel RL, Jirsch J

Insurance providers, patients and health systems bear the financial burden of liver failure caused by acetaminophen, not drug manufacturers

Pichler WJ, Daubner B, Kawabata T